| First Author | Wilhelm C | Year | 2011 |
| Journal | Nat Immunol | Volume | 12 |
| Issue | 11 | Pages | 1071-7 |
| PubMed ID | 21983833 | Mgi Jnum | J:177640 |
| Mgi Id | MGI:5295780 | Doi | 10.1038/ni.2133 |
| Citation | Wilhelm C, et al. (2011) An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12(11):1071-7 |
| abstractText | Interleukin 9 (IL-9) is a cytokine linked to lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to map the fate of cells that have activated IL-9. We found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs). IL-9 production by ILCs depended on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies resulted in much lower expression of IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-9 in the regulation of type 2 helper T cell cytokines and responses. |
