| First Author | Chappaz S | Year | 2021 |
| Journal | Cell Rep | Volume | 36 |
| Issue | 3 | Pages | 109430 |
| PubMed ID | 34289356 | Mgi Jnum | J:323836 |
| Mgi Id | MGI:6876921 | Doi | 10.1016/j.celrep.2021.109430 |
| Citation | Chappaz S, et al. (2021) Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells. Cell Rep 36(3):109430 |
| abstractText | While the intrinsic apoptosis pathway is thought to play a central role in shaping the B cell lineage, its precise role in mature B cell homeostasis remains elusive. Using mice in which mature B cells are unable to undergo apoptotic cell death, we show that apoptosis constrains follicular B (FoB) cell lifespan but plays no role in marginal zone B (MZB) cell homeostasis. In these mice, FoB cells accumulate abnormally. This intensifies intercellular competition for BAFF, resulting in a contraction of the MZB cell compartment, and reducing the growth, trafficking, and fitness of FoB cells. Diminished BAFF signaling dampens the non-canonical NF-kappaB pathway, undermining FoB cell growth despite the concurrent triggering of a protective p53 response. Thus, MZB and FoB cells exhibit a differential requirement for the intrinsic apoptosis pathway. Homeostatic apoptosis constrains the size of the FoB cell compartment, thereby preventing competition-induced FoB cell atrophy. |
