| First Author | Gibson MJ | Year | 1984 |
| Journal | Science | Volume | 225 |
| Issue | 4665 | Pages | 949-51 |
| PubMed ID | 6382608 | Mgi Jnum | J:7574 |
| Mgi Id | MGI:56044 | Doi | 10.1126/science.6382608 |
| Citation | Gibson MJ, et al. (1984) Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts. Science 225(4665):949-51 |
| abstractText | Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains. |
