| First Author | Miyakawa T | Year | 2001 |
| Journal | Behav Brain Res | Volume | 122 |
| Issue | 1 | Pages | 51-6 |
| PubMed ID | 11287076 | Mgi Jnum | J:128801 |
| Mgi Id | MGI:3768033 | Doi | 10.1016/s0166-4328(01)00171-1 |
| Citation | Miyakawa T, et al. (2001) Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression. Behav Brain Res 122(1):51-6 |
| abstractText | Fyn tyrosine kinase is highly expressed in the limbic system and mice lacking Fyn tyrosine kinase showed increased fearfulness in a variety of tests for anxiety-related behaviors. To investigate the possible role of Fyn tyrosine kinase in aggression, we assessed the aggressive behaviors of the mice lacking the Fyn tyrosine kinase using the resident-intruder and restraint-induced target biting paradigms. The percentage of Fyn-deficient mice that attacked an inanimate target in a restraint tube was higher than that of the control mice. On the contrary, in the resident-intruder paradigm, the percentage of Fyn-deficient mice that attacked the intruder was lower and the Fyn-deficient mice showed a longer latency to attack an intruder. These results suggest a distinct role of Fyn tyrosine kinase in enhancing the offensive aggression and decreasing the defensive aggression. A possible influence of anxiety-phenotype of the Fyn-deficient mice on their abnormal aggressive behavior was discussed. |
