| First Author | Spiessberger B | Year | 2009 |
| Journal | FEBS J | Volume | 276 |
| Issue | 4 | Pages | 1007-13 |
| PubMed ID | 19154345 | Mgi Jnum | J:147889 |
| Mgi Id | MGI:3842872 | Doi | 10.1111/j.1742-4658.2008.06839.x |
| Citation | Spiessberger B, et al. (2009) cGMP-dependent protein kinase II and aldosterone secretion. FEBS J 276(4):1007-13 |
| abstractText | ACTH-stimulated aldosterone secretion can be inhibited by atrio-natriuretic peptide/cGMP. The mechanism behind this modulation has been reported to involve cGMP-dependent activation of phosphodiesterase 2 (PDE2) and hydrolysis of cAMP. Recently it was reported that activation of cGMP-dependent protein kinase II (cGKII) stimulated aldosterone secretion in rat zona glomerulosa cells. The zona glomerulosa of the murine adrenal cortex expresses cGKII and PDE2. We used mice with a homozygous inactivation of the cGKII gene to investigate in vivo the potential role of this kinase in aldosterone secretion. Basal plasma renin and aldosterone levels were similar in wild-type and cGKII(-/-) mice. In vivo injection of atrio-natriuretic peptide decreased ACTH-stimulated aldosterone secretion in wild-type mice, but had no effect in cGKII-deficient mice. These results support the view that cGKII modulates aldosterone secretion in the murine adrenal cortex. |
