| First Author | Liu K | Year | 2015 |
| Journal | Neurosci Lett | Volume | 597 |
| Pages | 97-103 | PubMed ID | 25916881 |
| Mgi Jnum | J:316167 | Mgi Id | MGI:6831559 |
| Doi | 10.1016/j.neulet.2015.04.034 | Citation | Liu K, et al. (2015) Galphas regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neurosci Lett 597:97-103 |
| abstractText | Asymmetric cell division, which plays fundamental roles in generating cell diversity during development, requires elaborate interactions between extrinsic cues and intrinsic cues. However, the precise nature of this type of interaction and its involving signaling mechanisms are poorly understood. Here, we demonstrate that Galphas is present in the proliferative region of ventricular zone in mouse developing neocortex and co-localizes with intrinsic cell fate determinant protein Numb in dividing apical progenitors. Targeted ablation of Galphas subunit in the cortical progenitor causes an alteration from asymmetric to symmetric cell division, consequently leading to increased progenitor proliferation. Mechanistically, we show that Galphas deletion significantly reduces Numb expression and activates notch signaling. Therefore, these results reveal a novel role of Galphas in control of neural progenitor asymmetric cell division via suppressing Numb mediated Notch signaling inhibition. |
