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Publication : Distinct molecular profiles of skull bone marrow in health and neurological disorders.

First Author  Kolabas ZI Year  2023
Journal  Cell Volume  186
Issue  17 Pages  3706-3725.e29
PubMed ID  37562402 Mgi Jnum  J:339343
Mgi Id  MGI:7521872 Doi  10.1016/j.cell.2023.07.009
Citation  Kolabas ZI, et al. (2023) Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell 186(17):3706-3725.e29
abstractText  The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.
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