| First Author | Watanabe Y | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 13508 | PubMed ID | 27869116 |
| Mgi Jnum | J:243077 | Mgi Id | MGI:5907569 |
| Doi | 10.1038/ncomms13508 | Citation | Watanabe Y, et al. (2016) Autophagy controls centrosome number by degrading Cep63. Nat Commun 7:13508 |
| abstractText | Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin-proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62-/- mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63. |
