| First Author | Cheng M | Year | 2024 |
| Journal | Cell Rep | Volume | 43 |
| Issue | 2 | Pages | 113786 |
| PubMed ID | 38363684 | Mgi Jnum | J:350669 |
| Mgi Id | MGI:7613940 | Doi | 10.1016/j.celrep.2024.113786 |
| Citation | Cheng M, et al. (2024) RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis. Cell Rep 43(2):113786 |
| abstractText | Type 1 innate lymphoid cells (ILC1s) possess adaptive immune features, which confer antigen-specific memory responses against haptens and viruses. However, the transcriptional regulation of memory ILC1 responses is currently not known. We show that retinoic acid receptor-related orphan receptor alpha (RORalpha) has high expression in memory ILC1s in murine contact hypersensitivity (CHS) models. RORalpha deficiency diminishes ILC1-mediated CHS responses significantly but has no effect on memory T cell-mediated CHS responses. During sensitization, RORalpha promotes sensitized-ILC1 expansion by suppressing expression of cell-cycle repressors in draining lymph nodes. RORalpha programs gene-expression patterns related to cell survival and is required for the long-term maintenance of memory ILC1s in the liver. Our findings reveal RORalpha to be a key transcriptional factor for sensitized-ILC1 expansion and long-term maintenance of memory ILC1s. |
