| First Author | Smyth MJ | Year | 1999 |
| Journal | Cell Immunol | Volume | 196 |
| Issue | 1 | Pages | 51-9 |
| PubMed ID | 10486155 | Mgi Jnum | J:57956 |
| Mgi Id | MGI:1346242 | Doi | 10.1006/cimm.1999.1536 |
| Citation | Smyth MJ, et al. (1999) Perforin-dependent cytolytic responses in beta2-microglobulin-deficient mice. Cell Immunol 196(1):51-9 |
| abstractText | The ability of beta2-microglobulin-deficient mice (B6.beta2micro(o)) mice to reject syngeneic and major histocompatability (MHC) class I-deficient tumor grafts was examined with a view to determining residual cytotoxic activities that exist in these mice. In particular, the cytotoxic activities of NK cells and CD8(+) cytotoxic T lymphocytes (CTL) reactive against self-MHC class I were assessed using a variety of gene-targeted mice. The creation of mice doubly deficient for perforin and beta2micro (B6.P(o).beta2micro(o)) enabled the determination that perforin was responsible for the cytotoxic activity of NK cells and CD8(+) CTL reactive against self-MHC class I. Dependence on perforin function was demonstrated for the cytotoxicity of these effectors in vitro and for the ability of these effectors to reject a variety of tumors in vivo. Copyright 1999 Academic Press. |
