| First Author | Arens R | Year | 2005 |
| Journal | J Immunol | Volume | 174 |
| Issue | 10 | Pages | 5915-20 |
| PubMed ID | 15879081 | Mgi Jnum | J:98994 |
| Mgi Id | MGI:3580947 | Doi | 10.4049/jimmunol.174.10.5915 |
| Citation | Arens R, et al. (2005) Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. J Immunol 174(10):5915-20 |
| abstractText | The elimination of activated T cells is important to maintain homeostasis and avoid immunopathology. CD95 (Fas/APO-1) has been identified as a death mediator for activated T cells in vitro but the function of CD95 in death of mature T cells in vivo is still controversial. Here we show that triggering of the costimulatory TNF receptor family member CD27 sensitized T cells for CD95-induced apoptosis. CD95-deficient (lpr/lpr) T cells massively expanded and differentiated into IFN-gamma-secreting effector cells in transgenic mice that constitutively express the CD27 ligand, CD70. Concomitantly, CD95-deficient CD70 transgenic mice became moribund by 4 wk of age with severe liver pathology and bone marrow failure. These findings establish that CD95 is a critical regulator of effector T cell homeostasis in chronic immune activation. |
