Primary Identifier | MGI:7341861 | Allele Type | Transgenic |
Attribute String | Reporter | Gene | Tg(Rr280-EGFP)7Mrub |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The transgene contains the following: the Pomc gene, including sequence 8 kb downstream of the transcription start site and 13 kb upstream, containing the promoter and pituitary-specific enhancer Rr281 (with the neuron-specific enhancer Rr279 deleted but Rr280 still present), with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. The transgene is expressed in pituitary melanotrophs and corticotrophs and in hypothalamic arcuate neurons during embryonic development. |