| First Author | Gause WC | Year | 1997 |
| Journal | J Immunol | Volume | 158 |
| Issue | 9 | Pages | 4082-7 |
| PubMed ID | 9126966 | Mgi Jnum | J:110674 |
| Mgi Id | MGI:3640870 | Doi | 10.4049/jimmunol.158.9.4082 |
| Citation | Gause WC, et al. (1997) CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response. J Immunol 158(9):4082-7 |
| abstractText | T cell differentiation to effector cell function is required for the development of a type 2 immune response. The T cell surface molecule, CD28, is widely considered to be the principal costimulatory molecule involved in T cell differentiation to effector function, including IL-4 production, although this has been difficult to directly examine in vivo. We have studied in vivo differentiation to T cell effector function during two type 2 immune responses in CD28 knockout mice: the systemic immune response to goat anti-mouse IgD Ab and the mucosal immune response following oral inoculation with the nematode parasite, Heligmosomoides polygyrus. Our results show that in C57BL/6 CD28 knockout mice elevations in IL-4 gene expression and protein secretion are blocked during the immune response to goat anti-mouse IgD, and associated increases in serum IgG1 and IgE are also inhibited to untreated control levels. In marked contrast, T cell differentiation to IL-4 production is comparable in C57BL/6 CD28 -/- and CD28 +/+ H. polygyrus-inoculated mice, and elevations in both serum IgG1 and IgE levels occur. These results indicate that the specific kind of type 2 immune response determines whether T cell differentiation to IL-4 production is CD28 dependent. |
