| First Author | Faedo A | Year | 2008 |
| Journal | Cereb Cortex | Volume | 18 |
| Issue | 9 | Pages | 2117-31 |
| PubMed ID | 18165280 | Mgi Jnum | J:146820 |
| Mgi Id | MGI:3838633 | Doi | 10.1093/cercor/bhm238 |
| Citation | Faedo A, et al. (2008) COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex 18(9):2117-31 |
| abstractText | A major unsolved question in cortical development is how proliferation, neurogenesis, regional growth, regional identity, and laminar fate specification are coordinated. Here we provide evidence, using loss-of-function and gain-of-function manipulations, that the COUP-TFI orphan nuclear receptor promotes ventral cortical fate, promotes cell cycle exit and neural differentiation, regulates the balance of early- and late-born neurons, and regulates the balanced production of different types of layer V cortical projection neurons. We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling. |
