| First Author | Holcomb VB | Year | 2008 |
| Journal | Cancer Res | Volume | 68 |
| Issue | 22 | Pages | 9497-502 |
| PubMed ID | 19010925 | Mgi Jnum | J:141382 |
| Mgi Id | MGI:3818196 | Doi | 10.1158/0008-5472.CAN-08-2085 |
| Citation | Holcomb VB, et al. (2008) Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res 68(22):9497-502 |
| abstractText | Ku80 facilitates DNA repair and therefore should suppress cancer. However, ku80(-/-) mice exhibit reduced cancer, although they age prematurely and have a shortened life span. We tested the hypothesis that Ku80 deletion suppresses cancer by enhancing cellular tumor-suppressive responses to inefficiently repaired DNA damage. In support of this hypothesis, Ku80 deletion ameliorated tumor burden in APC(MIN) mice and increased a p53-mediated DNA damage response, DNA lesions, and chromosomal rearrangements. Thus, contrary to its assumed role as a caretaker tumor suppressor, Ku80 facilitates tumor growth most likely by dampening baseline cellular DNA damage responses. |
