Primary Identifier | MGI:5056283 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Cd1d1 |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
description | Because the C57BL/6 ES cells used to generate the allele contain a natural frameshift mutation in Cd1d2 that prevents its surface expression, deletion of Cd1d1 is sufficient to abolish all CD1D protein from the cell surface. |
molecularNote | Exons 2-6 were flanked by loxP sites. Flp-mediated recombination removed the neo cassette. |