| First Author | Rosenblatt N | Year | 1994 |
| Journal | Immunology | Volume | 83 |
| Issue | 3 | Pages | 476-83 |
| PubMed ID | 7835973 | Mgi Jnum | J:21189 |
| Mgi Id | MGI:69221 | Citation | Rosenblatt N, et al. (1994) The Yaa gene-dependent B-cell deficiency worsens the generalized lymphadenopathy and autoimmunity of C57BL/6-gld male mice. Immunology 83(3):476-83 |
| abstractText | The BXSB mice are unique among murine models for systemic lupus erythematosus in that males are much more severely affected than females. The BXSB male disease is associated with a Y-chromosome-linked gene, which is an autoimmunity accelerator gene (Yaa). The Yaa mutation affects the B-cell subset, which becomes hyper-responsive to T-cell signals. The Yaa mutation was combined to the generalized lymphadenopathy disease (gld) gene in order to know whether an additional intrinsic B-cell defect might enhance gld disease in the male mice. The B6-gld-Yaa male mice were shown to display earlier and exacerbated lymphoproliferative and autoimmune features. It appeared that the milder gld syndrome observed in B6-gld male mice with a normal Y-chromosome was dependent on the mechanisms of B-cell activation and that the B cells could also accelerate the lymphoproliferation and the differentiation of T cells into Thy-1+ B220+ cells. |
