| First Author | Huang CY | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 7 | Pages | 3259-65 |
| PubMed ID | 11907080 | Mgi Jnum | J:126392 |
| Mgi Id | MGI:3761201 | Doi | 10.4049/jimmunol.168.7.3259 |
| Citation | Huang CY, et al. (2002) Superantigen-induced TCR alpha locus secondary rearrangement: role in tolerance induction. J Immunol 168(7):3259-65 |
| abstractText | Immunization with superantigen in vivo induces transient activation of superantigen-specific T cells, followed by a superantigen-nonresponsive state. In this study, using a TCR alpha knock-in mouse in which the knock-in alpha-chain can be replaced with endogenous alpha-chain through secondary rearrangement, we show that immunization of superantigen changes the TCR alpha-chain expression on peripheral superantigen-specific T cells, induces expression of recombination-activating genes, and generates DNA double-strand breaks at the TCR alpha-chain locus. These results suggest that viral superantigens are capable of inducing peripheral TCR revision. Our findings thus provide a new perspective on pathogen-immune system interaction. |
