| First Author | Sato-Hashimoto M | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 30910011 | Mgi Jnum | J:274693 |
| Mgi Id | MGI:6304130 | Doi | 10.7554/eLife.42025 |
| Citation | Sato-Hashimoto M, et al. (2019) Microglial SIRPalpha regulates the emergence of CD11c(+) microglia and demyelination damage in white matter. Elife 8:e42025 |
| abstractText | A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c(+) microglia, as well as the mechanism of its induction, are poorly understood. Here we report that the genetic ablation of signal regulatory protein alpha (SIRPalpha), a membrane protein, induced the emergence of CD11c(+) microglia in the brain white matter. Mice lacking CD47, a physiological ligand of SIRPalpha, and microglia-specific SIRPalpha-knockout mice exhibited the same phenotype, suggesting that an interaction between microglial SIRPalpha and CD47 on neighbouring cells suppressed the emergence of CD11c(+) microglia. A lack of SIRPalpha did not cause detectable damage to the white matter, but resulted in the increased expression of genes whose expression is characteristic of the repair phase after demyelination. In addition, cuprizone-induced demyelination was alleviated by the microglia-specific ablation of SIRPalpha. Thus, microglial SIRPalpha suppresses the induction of CD11c(+) microglia that have the potential to accelerate the repair of damaged white matter. |
