| Primary Identifier | MGI:5646021 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Ank2 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An L1622I (CTG to ATC) mutation in exon 19 and a loxP site flanked neomycin resistance gene cassette were knocked into the gene. In humans, the mutation is involved with the setting of hereditary cardiac arrhythmia. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed reduced protein expression in the fat, liver, skeletal muscle, pancreatic beta cells, mouse embryonic fibroblasts and heart but not the brain. |
