| First Author | Chen CF | Year | 2017 |
| Journal | Cell Rep | Volume | 18 |
| Issue | 10 | Pages | 2331-2342 |
| PubMed ID | 28273450 | Mgi Jnum | J:251063 |
| Mgi Id | MGI:6103300 | Doi | 10.1016/j.celrep.2017.02.040 |
| Citation | Chen CF, et al. (2017) ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment. Cell Rep 18(10):2331-2342 |
| abstractText | Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repairs UV-induced DNA damage and is required for cellular proliferation. ATR mutant tumors exhibit both the accumulation of multiple mutations and the altered expression of inflammatory genes, resulting in decreased T cell recruitment and increased recruitment of macrophages known to spur tumor invasion. Taken together, these studies identify a mechanism by which melanoma cells modulate the immune microenvironment to promote continued growth. |
