| Primary Identifier | MGI:5311563 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Plec |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A C to T mutation at postion 5995 resulting in a Arg2110Trp substitution was introduced in exon 31 and a floxed neo cassette was inserted in the intron between exons 31 and 32 via homologous recombination. Cre mediated recombination removed the neo cassette. Protein expression of P1a, but not P1c, is reduced in primary keratinocyte lysates from heterozygous and homozygous mice. |
