| First Author | Joyner AL | Year | 1991 |
| Journal | Science | Volume | 251 |
| Issue | 4998 | Pages | 1239-43 |
| PubMed ID | 1672471 | Mgi Jnum | J:67524 |
| Mgi Id | MGI:1930772 | Doi | 10.1126/science.1672471 |
| Citation | Joyner AL, et al. (1991) Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 251(4998):1239-43 |
| abstractText | The two mouse genes, En-1 and En-2, that are homologs of the Drosophila segmentation gene engrailed, show overlapping spatially restricted patterns of expression in the neural tube during embryogenesis, suggestive of a role in regional specification. Mice homozygous for a targeted mutation that deletes the homeobox were viable and showed no obvious defects in embryonic development. This may be due to functional redundancy of En-2 and the related En-1 gene product during embryogenesis. Consistent with this hypothesis, the mutant mice showed abnormal foliation in the adult cerebellum, where En-2, and not En-1, is normally expressed. |
