| First Author | Huffnagle GB | Year | 1999 |
| Journal | J Immunol | Volume | 163 |
| Issue | 9 | Pages | 4642-6 |
| PubMed ID | 10528159 | Mgi Jnum | J:64293 |
| Mgi Id | MGI:1889062 | Doi | 10.4049/jimmunol.163.9.4642 |
| Citation | Huffnagle GB, et al. (1999) Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol 163(9):4642-6 |
| abstractText | After intratracheal inoculation of the AIDS-associated pathogen Cryptococcus neoformans, 12-wk survival was >90% for CCR5+/+ mice but <25% for CCR5-/- mice. There were no defects in lung leukocyte recruitment (wk 5), pulmonary clearance, or delayed-type hypersensitivity in CCR5-/- mice. However, CCR5-/- mice had defects in leukocyte recruitment into the brain and, strikingly, in elimination of cryptococcal polysaccharide from the brain. In nonimmune CCR5-/- mice, there was a significant defect in macrophage recruitment after challenge with shed cryptococcal products (C. neoformans filtrate Ag) but not other nonspecific stimuli. Thus, CCR5 plays specific roles in innate immunity and organ-specific leukocyte trafficking during host defense against C. neoformans. |
