| Help | About | Contact Us

Allele : Cd274<em1Okat> CD274 antigen; endonuclease-mediated mutation 1, Taku Okazaki

Primary Identifier	MGI:6356539	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Cd274
Strain of Origin	C57BL/6N	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR mediated recombination introduced a single nucleotide insertion of a G resulting in the conversion of Y56 to a premature stop codon.

mutations:
Nucleotide substitutions

synonyms:
Cd274-,
Cd274-

earliestPublication:
Sugiura D, et al. (2019) Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses. Science 364(6440):558-566

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=73922486

MouseMine