| First Author | Chen JZ | Year | 2019 |
| Journal | Circ Rep | Volume | 1 |
| Issue | 5 | Pages | 199-205 |
| PubMed ID | 31123721 | Mgi Jnum | J:299062 |
| Mgi Id | MGI:6490113 | Doi | 10.1253/circrep.CR-18-0012 |
| Citation | Chen JZ, et al. (2019) Aortic Strain Correlates with Elastin Fragmentation in Fibrillin-1 Hypomorphic Mice. Circ Rep 1(5):199-205 |
| abstractText | Background: High frequency ultrasound has facilitated in vivo measurements of murine ascending aortas, allowing aortic strains to be gleaned from two-dimensional images. Thoracic aortic aneurysms associated with mutations in fibrillin-1 (FBN1) display elastin fragmentation, which may impact aortic strain. In this study, we determined the relationship between elastin fragmentation and aortic circumferential strain in wild type and fibrillin-1 hypomorphic (FBN1 (mgR/mgR)) mice. Methods and Results: Luminal diameters of the ascending aorta from wild type and FBN1 hypomorphic (FBN1 (mgR/mgR)) mice were measured in systole and diastole. Expansion of the ascending aorta during systole in male and female wild type mice was 0.21+/-0.02 mm (16.3%) and 0.21+/-0.01 mm (17.0%) respectively, while expansion in male and female FBN1 (mgR/mgR) mice was 0.11+/-0.04 mm (4.9%) and 0.07+/-0.02 mm (4.5%) respectively. Reduced circumferential strain was observed in FBN1 (mgR/mgR) mice compared to wild type littermates. Elastin fragmentation was inversely correlated to circumferential strain (R^2 = 0.628 p = 0.004) and significantly correlated with aortic diameter. (R^2 = 0.397, p = 0.038 in systole and R^2 = 0.515, p =0.013 in diastole). Conclusions: FBN1 (mgR/mgR) mice had increased aortic diameters, reduced circumferential strain, and increased elastin fragmentation. Elastin fragmentation in FBN1 (mgR/mgR) and their wild type littermates was correlated with reduced circumferential strain. |
