Primary Identifier | MGI:2182286 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Nkx6-2 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exons 1 through 3 were deleted by the insertion of a neomycin selection cassette. RT-PCR analysis and in situ hybridization of embryonic midbrain showed an absence of transcript in homozygous mutant mice. The expression of Nkx6-1 was shown to be unaffected by the targeting event via in situ hybridization. |