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Publication : Spontaneous tumors in nude mice: effect of the viable yellow gene.

First Author  Stutman O Year  1979
Journal  Exp Cell Biol Volume  47
Issue  2 Pages  129-35
PubMed ID  446837 Mgi Jnum  J:101552
Mgi Id  MGI:3604255 Doi  10.1159/000162929
Citation  Stutman O (1979) Spontaneous tumors in nude mice: effect of the viable yellow gene. Exp Cell Biol 47(2):129-35
abstractText  The incidence and type of spontaneous tumors in athymic nude (nu/nu) mice (partially inbred in CBA/H background) which were also carrying the viable yellow gene (Avy, derived from C57BL/6JAvy mice), were comparable to those observed in the phenotypically normal nu/+ and +/+ control crosses carrying the Avy gene. The Avy gene increases the incidence of spontaneous and induced tumors in most mouse strains. These results would argue against the thymus dependency of the putative immunological surveillance mechanisms.
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