| First Author | Tanaka S | Year | 1994 |
| Journal | Acta Anat (Basel) | Volume | 149 |
| Issue | 3 | Pages | 170-3 |
| PubMed ID | 7976166 | Mgi Jnum | J:19308 |
| Mgi Id | MGI:67485 | Doi | 10.1159/000147573 |
| Citation | Tanaka S, et al. (1994) Genetic association between agouti locus and adrenal X zone morphology in SM/J mice. Acta Anat (Basel) 149(3):170-3 |
| abstractText | We provide evidence for a genetic link between the adrenocortical X zone and the agouti (a) locus on chromosome 2 in the segregating inbred mouse strain SM/J. This strain has been established and maintained while keeping heterozygosity (Aw/a) at the a locus and is, therefore, of advantage in assessing the effects of these alleles upon physiological phenomena. In Aw/a (white-bellied agouti) or a/a (black) virgins, X zones were composed exclusively of nonvacuolated cells, while they contained vacuolated cells only in Aw/Aw. This suggested that the a locus might control the X zone morphology on the SM/J genetic background and that the a (nonagouti) allele is dominant in vacuolation of cells in this zone. The a locus might have a novel function in the control of the adrenocortical X zone cell turnover in addition to the well-known function controlling the coat color. |
