| First Author | Cohen P | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5579 | Pages | 240-3 |
| PubMed ID | 12114623 | Mgi Jnum | J:107879 |
| Mgi Id | MGI:3622408 | Doi | 10.1126/science.1071527 |
| Citation | Cohen P, et al. (2002) Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297(5579):240-3 |
| abstractText | Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. To examine the mechanism underlying leptin's metabolic actions, we used transcription profiling to identify leptin-regulated genes in ob/ob liver. Leptin was found to specifically repress RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the biosynthesis of monounsaturated fatty acids. Mice lacking SCD-1 were lean and hypermetabolic. ob/ob mice with mutations in SCD-1 were significantly less obese than ob/ob controls and had markedly increased energy expenditure. ob/ob mice with mutations in SCD-1 had histologically normal livers with significantly reduced triglyceride storage and VLDL (very low density lipoprotein) production. These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions. |
