| First Author | Adkison L | Year | 1989 |
| Journal | Mouse News Lett | Volume | 84 |
| Pages | 89-90 | Mgi Jnum | J:14251 |
| Mgi Id | MGI:62423 | Citation | Adkison L, et al. (1989) New alleles of "arrested development of righting response (adr)". Mouse News Lett 84:89-90 |
| abstractText | Full text of MNL contribution: New alleles of Òarrested development of righting response (adr)Ó. Arrested development of righting response and myotonia are allelic (Jockusch and Bertram, MNL 75:19-20). Homozygous mutants are characterized by stiffening of hindlimbs when supine with difficulty righting as well as a stiffening of hindlimbs after rapid movement. The phenotype produced by this autosomal, recessive mutation is recognizable at age 2 weeks and is progressive. SWR/J-adr<mto> mice have myotonic discharges in limbs, abdominal, tongue, and eye muscles (Heller and Sidman MNL 65:16, personal observation). The adr<mto> mutation may provide a useful model for electrical instability of muscle fiber membranes. Two new mutations have occurred at The Jackson Laboratory, in DBA/1J and BALB/cBy strains, that produce morphological symptoms similar to those produced by the SWR/J-adr<mto> mutation. Testing for allelism between the BALB/cBy mutation and SWR/J-adr<mto> has shown them to be allelic. Similarly, testing for allelism has shown the DBA/1J mutant and the BALB/cBy-adr<mto-2J> to also be allelic. Gene symbols for these new alleles are BALB/cBy-adr<mto-2J> and DBA/1J-adr<mto-3J>. DNA from these mutants will be available from the DNA Resource. |
