| First Author | Cook S | Year | 1993 |
| Journal | Mouse Genome | Volume | 91 |
| Pages | 554 | Mgi Jnum | J:28688 |
| Mgi Id | MGI:76231 | Citation | Cook S, et al. (1993) Re-mutation to Ames waltzer. Mouse Genome 91:554 |
| abstractText | Full text of Mouse Genome contribution: Research News: 1. Re-mutation to Ames waltzer. Two independent re-mutations to Ames waltzer have spontaneously occurred at The Jackson Laboratory. B6C3Fe-a/a-av2J arose in a linkage cross between B6C3Fe-a/a and CHMU/Le. The av2J re-mutation has since been backcrossed to B6C3Fe-a/a for eight generations. The av3J re-mutation arose in C57BL/6J of Animal Resources and has been maintained on the original background. Both re-mutations display the head-tossing, circling, and deafness typical of the Ames waltzer phenotype, but the av2J/av2J mutant is more severely affected. Mutants of the av2J/av2J genotype are disoriented and sink in a swim test. Mutants of the av3J/av3J genotype resemble the first Jax mutation, B6.BKs-avJ, as they circle afloat and swim with difficulty. DNA is available from each mutation at the Ames waltzer locus on Chromosome 10 and each will be maintained as frozen embryos. (Sue Cook and Priscilla Lane) |
