| First Author | Martin-Orozco N | Year | 2009 |
| Journal | Immunity | Volume | 31 |
| Issue | 5 | Pages | 787-98 |
| PubMed ID | 19879162 | Mgi Jnum | J:158561 |
| Mgi Id | MGI:4439136 | Doi | 10.1016/j.immuni.2009.09.014 |
| Citation | Martin-Orozco N, et al. (2009) T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31(5):787-98 |
| abstractText | Although T helper 17 (Th17) cells have been found in tumor tissues, their function in cancer immunity is unclear. We found that interleukin-17A (IL-17A)-deficient mice were more susceptible to developing lung melanoma. Conversely, adoptive T cell therapy with tumor-specific Th17 cells prevented tumor development. Importantly, the Th17 cells retained their cytokine signature and exhibited stronger therapeutic efficacy than Th1 cells. Unexpectedly, therapy using Th17 cells elicited a remarkable activation of tumor-specific CD8(+) T cells, which were necessary for the antitumor effect. Th17 cells promoted dendritic cell recruitment into the tumor tissues and in draining lymph nodes increased CD8 alpha(+) dendritic cells containing tumor material. Moreover, Th17 cells promoted CCL20 chemokine production by tumor tissues, and tumor-bearing CCR6-deficient mice did not respond to Th17 cell therapy. Thus, Th17 cells elicited a protective inflammation that promotes the activation of tumor-specific CD8(+) T cells. These findings have important implications in antitumor immunotherapies. |
