| First Author | Fernandez NC | Year | 1999 |
| Journal | Nat Med | Volume | 5 |
| Issue | 4 | Pages | 405-11 |
| PubMed ID | 10202929 | Mgi Jnum | J:54135 |
| Mgi Id | MGI:1334133 | Doi | 10.1038/7403 |
| Citation | Fernandez NC, et al. (1999) Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 5(4):405-11 |
| abstractText | Cytotoxic T lymphocytes and natural killer cells are essential effectors of anti-tumor immune responses in vivo. Dendritic cells (DC) 'prime' tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded DC promoted NK cell- dependent anti-tumor effects. In vitro studies demonstrated a cell-to- cell contact between DC and resting NK cells that resulted in a substantial increase in both NK cell cytolytic activity and IFN-gamma production. Thus, DC are involved in the interaction between innate and adaptive immune responses. |
