| First Author | Mosier DE | Year | 1993 |
| Journal | J Exp Med | Volume | 177 |
| Issue | 1 | Pages | 191-4 |
| PubMed ID | 8418200 | Mgi Jnum | J:3479 |
| Mgi Id | MGI:51992 | Doi | 10.1084/jem.177.1.191 |
| Citation | Mosier DE, et al. (1993) Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J Exp Med 177(1):191-4 |
| abstractText | The autosomal recessive scid mutation results in defective immunoglobulin and T cell receptor gene rearrangement. The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C.B-17 scid mice spontaneously produce both T cells and immunoglobulin, a phenotype known as leaky. Moreover, introduction of neonatal T cells into C.B-17 scid mice leads to immunoglobulin production by 100% of animals. We have produced mice homozygous for both the scid and beige mutations. By contrast with C.B-17 scid mice, BALB/c scid.beige mice have a < 2% incidence of leakiness. This percentage does not increase with age, and introduction of neonatal T cells fails to rescue immunoglobulin production. This suggests that a gene (or genes) closely linked to the beige locus regulates B and/or T cell development. |
