| First Author | Kaido T | Year | 1993 |
| Journal | Int J Cancer | Volume | 54 |
| Issue | 3 | Pages | 475-81 |
| PubMed ID | 8509222 | Mgi Jnum | J:12190 |
| Mgi Id | MGI:60440 | Doi | 10.1002/ijc.2910540320 |
| Citation | Kaido T, et al. (1993) Sensitized T lymphocytes render DBA/2 beige mice responsive to IFN alpha/beta therapy of Friend erythroleukemia visceral metastases. Int J Cancer 54(3):475-81 |
| abstractText | Interferon alpha/beta (IFN alpha/beta) is highly effective in inhibiting the development of Friend erythroleukemia cell (FLC) visceral metastases in DBA/2 mice injected intravenously (i.v.) with FLC, but does not protect FLC-injected DBA/2 beige (bg/bg) mice. Use of IFN alpha/beta-resistance FLC indicated that IFN was acting through host mechanisms in DBA/2 mice and thus pointed to a defect in some host mechanism in bg/bg mice essential for IFN's anti-metastatic action. We undertook experiments to restore in bg/bg mice the marked anti-FLC metastatic effect of IFN alpha/beta observed in DBA/2 and +/bg mice. Adoptive transfer of spleen cells from normal syngeneic mice to IFN-treated bg/bg mice was ineffective, but the transfer of splenic T lymphocytes from FLC-immunized DBA/2 or +/bg mice markedly increased the survival time of FLC-injected bg/bg mice provided that these mice were also treated with IFN alpha/beta. Neither treatment alone resulted in an increase in survival time. As few as 1 x 10(7) immune spleen cells were effective in IFN-treated FLC-injected bg/bg mice. The T-cell immune response to FLC of bg/bg mice was diminished compared with that of +/bg mice. Likewise, only combination therapy of immune spleen cells and IFN alpha/beta resulted in an increased survival time of ESb-lymphoma-injected bg/bg mice. Our results indicate the essential participation both of T-cell-mediated immune mechanisms and of IFN alpha/beta in the inhibition of FLC visceral metastases. |
