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Publication : Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice.

First Author  Ahmed F Year  1985
Journal  J Hered Volume  76
Issue  4 Pages  311-2
PubMed ID  4031470 Mgi Jnum  J:7980
Mgi Id  MGI:56449 Doi  10.1093/oxfordjournals.jhered.a110101
Citation  Ahmed F, et al. (1985) Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice. J Hered 76(4):311-2
abstractText  Beige, bg, and reduced pigmentation, rp, are recessive mutations affecting lysosomal function. Homozygosity for beige prevented lipofuscinosis of the spleen in C57BL mice and its incidence was greatly reduced by homozygosity for rp. Dilute (d) homozygotes, with normal lysosomes, were susceptible to lipofuscinosis even though their melanosomes were more severely affected than those of beige mice.
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