| First Author | Carlson GA | Year | 1984 |
| Journal | Cell Immunol | Volume | 87 |
| Issue | 2 | Pages | 348-56 |
| PubMed ID | 6467382 | Mgi Jnum | J:7539 |
| Mgi Id | MGI:56009 | Doi | 10.1016/0008-8749(84)90004-2 |
| Citation | Carlson GA, et al. (1984) Adaptive immune defects and delayed rejection of allogeneic tumor cells in beige mice. Cell Immunol 87(2):348-56 |
| abstractText | The effect of the beige (bg) mutation on adaptive allogeneic tumor rejection was examined by monitoring tumor cell survival in vivo using [131I]iododeoxyuridine-prelabeled cells. Accelerated elimination of allogeneic tumor cells normally begins 8 days after ip injection and is due to active immune responses. Two independent mutations to beige on two different inbred backgrounds (C57BL/6J bgJ and DBA/2JCo bg8J) were tested, and bg/bg mice showed a 1-day delay in immune elimination of allogeneic cells. This delayed rejection was not due to a defect in clearing label from dead cells, nor to an inability to effect antibody-induced killing in vivo. Both humoral and cell-mediated responses against the allogeneic tumor cells were significantly lower in bg/bg than in +/bg mice. |
