| First Author | Cattanach BM | Year | 1988 |
| Journal | Mouse News Lett | Volume | 81 |
| Pages | 64 | Mgi Jnum | J:12721 |
| Mgi Id | MGI:60943 | Citation | Cattanach BM, et al. (1988) Dark-eyed albinism, c44H. Mouse News Lett 81:64 |
| abstractText | Full text of MNL contribution. 2. Dark-eyed albinism. Homozygotes for a new albino allele (c-44H) have dark eyes and traces of pigmented hair in the ano-genital area. Indications of the dark eyes can be observed at birth and are reliable enough to permit accurate classification in crosses where c and c-44H are segregating. When the eyes open they are seen to be darker than those of c animals and the distinction becomes more obvious with age. Thus, at weaning c-44H mice have dark ruby eyes and at 3-4 months the eyes are nearly black. The hair pigmentation has also only been noted in older animals. Since the extremities (ears. nose and tail) show no trace of pigmentation it seemed unlikely that c-44H was a temperature sensitive mutation like ch and, indeed, lowering the environmental temperature did not influence the extent of coat pigmentation. It is not yet entirely clear whether c-44H is dominant or recessive to c; some, but not all cc-44H heterozygotes appear to have a darker than normal c eye colour. C-44Hc-ch heterozygotes, as might be expected, are indistinguishable from cc-ch animals; and pc-44H/pc-44H homozygotes have pink eyes and white coats like pc-ch/pc-ch mice. C-44H homozygotes are fully viable and fertile in both sexes. (Cattanach and Rasberry) |
