| First Author | Kratochvilova J | Year | 1988 |
| Journal | Mutat Res | Volume | 198 |
| Issue | 2 | Pages | 295-301 |
| PubMed ID | 3352637 | Mgi Jnum | J:24033 |
| Mgi Id | MGI:71820 | Doi | 10.1016/0027-5107(88)90006-1 |
| Citation | Kratochvilova J, et al. (1988) Dominant cataract and recessive specific-locus mutations detected in offspring of procarbazine-treated male mice. Mutat Res 198(2):295-301 |
| abstractText | The induction of dominant cataract mutations by procarbazine was studied concomitantly with the induction of specific-locus mutations in treated male mice. The most effective dose in the specific-locus test, 600 mg/kg of procarbazine, and a fractionated dose of 5 X 200 mg/kg were used. The frequencies of dominant cataract mutations were higher, but not significantly different from the historical control. The ratio between the number of recovered specific-locus and dominant cataract mutations was in accordance with that found in our experiments with gamma-rays (Ehling et al., 1982; Kratochvilova, 1981) or in experiments with ethylnitrosourea (Favor, 1986). A total of 3 dominant cataract mutations were recovered in the offspring of procarbazine-treated spermatogonial stem cells. Two mutations had complete penetrance while the third exhibited a reduced penetrance of approximately 70%. The viability and fertility of the heterozygotes of all 3 mutations were not affected. Only 1 mutation was shown to be viable as a homozygote. |
