| First Author | Tajbakhsh S | Year | 1997 |
| Journal | Cell | Volume | 89 |
| Issue | 1 | Pages | 127-38 |
| PubMed ID | 9094721 | Mgi Jnum | J:39308 |
| Mgi Id | MGI:86691 | Doi | 10.1016/s0092-8674(00)80189-0 |
| Citation | Tajbakhsh S, et al. (1997) Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD. Cell 89(1):127-38 |
| abstractText | We analyzed Pax-3 (splotch), Myf-5 (targeted with nlacZ), and splotch/Myf-5 homozygous mutant mice to investigate the roles that these genes play in programming skeletal myogenesis. In splotch and Myf-5 homozygous embryos, myogenic progenitor cell perturbations and early muscle defects are distinct. Remarkably, splotch/Myf-5 double homozygotes have a dramatic phenotype not seen in the individual mutants: body muscles are absent. MyoD does not rescue this double mutant phenotype since activation of this gene proves to be dependent on either Pax-3 or Myf-5. Therefore, Pax-3 and Myf-5 define two distinct myogenic pathways, and MyoD acts genetically downstream of these genes for myogenesis in the body. This genetic hierarchy does not appear to operate for head muscle formation. |
