| First Author | Epstein DJ | Year | 1991 |
| Journal | Genomics | Volume | 10 |
| Issue | 1 | Pages | 89-93 |
| PubMed ID | 2045114 | Mgi Jnum | J:11244 |
| Mgi Id | MGI:59683 | Doi | 10.1016/0888-7543(91)90488-z |
| Citation | Epstein DJ, et al. (1991) Molecular characterization of a deletion encompassing the splotch mutation on mouse chromosome 1. Genomics 10(1):89-93 |
| abstractText | We have used a set of markers newly assigned to the proximal portion of mouse chromosome 1 to characterize the chromosomal segment deleted in the splotch-retarded (Spr) mouse mutant. Among nine markers tested in the heterozygote Spr/+mouse, we have identified four genes, Vil, Des, Inha, and Akp-3, which map within the Spr deletion. The closest distal marker to the deletion is the Acrg gene, with the distal deletion breakpoint mapping within the 0.8-cM segment separating Akp-3 and Acrg. The most proximal gene to the Spr deletion is Tp1. The proximal deletion breakpoint maps within the 0.8-cM segment separating Tp1 and Vil. The minimum size of the Spr deletion would therefore be limited to 14 cM, the genetic distance between Vil and Akp-3. The maximum size of the Spr deletion is estimated to be 16 cM, the genetic distance between Tp1 and Acrg. |
