| First Author | Stott D | Year | 1993 |
| Journal | Genes Dev | Volume | 7 |
| Issue | 2 | Pages | 197-203 |
| PubMed ID | 8436292 | Mgi Jnum | J:3956 |
| Mgi Id | MGI:52461 | Doi | 10.1101/gad.7.2.197 |
| Citation | Stott D, et al. (1993) Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203 |
| abstractText | The mouse Brachyury (T) gene is required for normal development of axial structures. Embryos homozygous for the T mutation show severe deficiencies in mesoderm formation. They lack the notochord and allantois, have abnormal somites, and die at approximately 10 days postcoitum probably as a result of the allantois defect. Mice heterozygous for the T mutation exhibit a variable short-tailed phenotype. The T gene has been cloned and shown to be expressed in the tissues most strongly affected by the mutation. In this paper, we show that a single-copy transgene representing the wild-type T allele is able to rescue the T-associated tail phenotype. In addition, we show that increasing dosage of the T gene in Tc/+ mice causes an increased extension of the axis. These data show the correlation of the level of T product with the extension of the anteroposterior axis, directly demonstrating the involvement of the T product in this process. |
