| First Author | Búcan M | Year | 1987 |
| Journal | Genes Dev | Volume | 1 |
| Issue | 4 | Pages | 376-85 |
| PubMed ID | 3678828 | Mgi Jnum | J:8922 |
| Mgi Id | MGI:57387 | Doi | 10.1101/gad.1.4.376 |
| Citation | Bucan M, et al. (1987) Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex. Genes Dev 1(4):376-85 |
| abstractText | We have analyzed the genomic structure of three mouse t haplotypes of the t9 complementation group. Each of these t haplotypes, tw18, t4, and tks1, is known to have resulted from a rare recombination event between a complete t haplotype and a wild-type chromosome. Using molecular probes that identify sequences in the distal portion of the t complex, we have shown that each of these t haplotypes contains a similar (perhaps identical) deletion of one group of t complex sequences, and duplication of another group. These data suggest that the recombination events that produced these three t haplotypes involved similar unequal crossovers within the distal inversion. The deletion and duplication of genetic material associated with all members of the t9 complementation group tested provides a molecular explanation for the recessive lethal mutation associated with these t haplotypes. |
