| First Author | Washburn LL | Year | 1983 |
| Journal | Nature | Volume | 303 |
| Issue | 5915 | Pages | 338-40 |
| PubMed ID | 6855886 | Mgi Jnum | J:7073 |
| Mgi Id | MGI:55544 | Doi | 10.1038/303338a0 |
| Citation | Washburn LL, et al. (1983) Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature 303(5915):338-40 |
| abstractText | A Y-linked gene(s) is undoubtedly a prerequisite for testicular development in mammals. However, exceptional cases suggest that the mere presence of the Y chromosome or the Y-linked testis-determining gene does not totally control the fate of the bipotential gonad. For example, in the mouse, a major as yet unmapped autosomal locus is necessary for normal testicular development and at least one additional autosomal locus is implicated. We present here a third autosomal sex-determining locus. This dominantly inherited trait, tentatively named T-associated sex reversal (gene symbol Tas), is closely linked to or a part of the T/t complex on chromosome 17 of the mouse. Gonads of chromosomally XY individuals who inherit Tas on the C57BL/6J inbred strain background differentiate as ovaries or ovotestes. |
