| First Author | Murashima-Suginami A | Year | 2021 |
| Journal | Sci Adv | Volume | 7 |
| Issue | 7 | PubMed ID | 33579703 |
| Mgi Jnum | J:325421 | Mgi Id | MGI:6727696 |
| Doi | 10.1126/sciadv.abf1798 | Citation | Murashima-Suginami A, et al. (2021) Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling. Sci Adv 7(7) |
| abstractText | Uterine sensitization-associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor-related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG-1 plays key regulatory roles in suppressing tooth development. However, the involvement of USAG-1 in various types of congenital tooth agenesis remains unknown. Here, we show that blocking USAG-1 function through USAG-1 knockout or anti-USAG-1 antibody administration relieves congenital tooth agenesis caused by various genetic abnormalities in mice. Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti-USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy. |
