| First Author | Kilbourn MR | Year | 1995 |
| Journal | Nucl Med Biol | Volume | 22 |
| Issue | 5 | Pages | 565-7 |
| PubMed ID | 7581164 | Mgi Jnum | J:28256 |
| Mgi Id | MGI:75879 | Doi | 10.1016/0969-8051(95)00005-i |
| Citation | Kilbourn MR, et al. (1995) Mutant mouse strains as models for in vivo radiotracer evaluations: [11C]methoxytetrabenazine ([11C]MTBZ) in tottering mice. Nucl Med Biol 22(5):565-7 |
| abstractText | The regional brain distribution of [11C]methoxytetrabenazine ([11C]MTBZ), a high affinity radioligand for the vesicular monoamine transporter, has been examined in normal and tottering mice, which are neurological mutants. The tottering mice show significantly higher radiotracer accumulation (150-195% of controls) in all brain regions examined (striatum, cortex, hippocampus, hypothalamus, cerebellum and thalamus). The increases in [11C]MTBZ binding correlate (r = 0.91) with the reported increases in norepinephrine concentrations in these regions, and are consistent with the noradrenergic hyperinnervation characteristic of the tottering mutant mouse. These studies demonstrate that a mutant mouse model of increased innervation can be used to evaluate the sensitivity of an in vivo radiotracer measure, in this case [11C]MTBZ binding to vesicular transporters, to an increase in the numbers of binding sites in specific regions of the brain. |
