| First Author | Patel VK | Year | 1991 |
| Journal | Brain Res Bull | Volume | 27 |
| Issue | 6 | Pages | 849-52 |
| PubMed ID | 1686215 | Mgi Jnum | J:633 |
| Mgi Id | MGI:49169 | Doi | 10.1016/0361-9230(91)90221-5 |
| Citation | Patel VK, et al. (1991) Increased methionine-enkephalin levels in genetically epileptic (tg/tg) mice. Brain Res Bull 27(6):849-52 |
| abstractText | Recent experimental data indicate that endogenous brain ligands for the opioid receptors such as enkephalins, beta-endorphin (beta-End) and dynorphin (Dyn) may be involved in both generalized and partial seizures. The tottering (tg/tg) mouse provides an electrophysiological representation of generalized spontaneous human epilepsy. These mice exhibit behavioral absence seizures with accompanying spike-wave discharges. Methionine-enkephalin (M-Enk), beta-End and Dyn levels in various regions of brain were measured by radioimmunoassay (RIA) in 15-18-week-old tg/tg and control (+/+) mice to elucidate the relation between seizures and the opioid system. beta-End and Dyn levels were similar in tg/tg and +/+ mice. However, M-Enk levels were significantly increased in the striatum, cortex, pons and medulla of the tg/tg mice. Our data suggest that in the tottering mouse model of generalized epilepsy there is an alteration of enkephalinergic pathways and not of the endorphinergic or dynorphinergic pathways. |
