| First Author | Ogasawara M | Year | 2001 |
| Journal | FEBS Lett | Volume | 508 |
| Issue | 2 | Pages | 181-6 |
| PubMed ID | 11718712 | Mgi Jnum | J:72853 |
| Mgi Id | MGI:2153687 | Doi | 10.1016/s0014-5793(01)03052-6 |
| Citation | Ogasawara M, et al. (2001) Characterization of acute somatosensory pain transmission in P/Q-type Ca(2+) channel mutant mice, leaner. FEBS Lett 508(2):181-6 |
| abstractText | To study the role of the Ca(v)2.1/alpha(1A) (P/Q-type) Ca(2+) channel in somatosensory pain processing, behavioral and electrophysiological studies were conducted using the leaner (tg(la)/tg(la)) mouse. Behavioral analyses in tg(la)/tg(la) revealed reduced responses to mechanical stimuli, and enhanced responses to heat stimuli. Electrophysiological analyses showed that tg(la)/tg(la) had a significantly reduced ability to evoke dorsal root potentials, suggesting a functional deficit in the spinal dorsal horn local circuitry responsible for presynaptic inhibition of primary sensory fibers. These results suggest the critical importance of the P/Q-type channel in modulation of acute somatosensory pain transmission in spinal cord. |
