| First Author | Xiao E | Year | 2017 |
| Journal | Cell Host Microbe | Volume | 22 |
| Issue | 1 | Pages | 120-128.e4 |
| PubMed ID | 28704648 | Mgi Jnum | J:272675 |
| Mgi Id | MGI:6284983 | Doi | 10.1016/j.chom.2017.06.014 |
| Citation | Xiao E, et al. (2017) Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity. Cell Host Microbe 22(1):120-128.e4 |
| abstractText | Diabetes is a risk factor for periodontitis, an inflammatory bone disorder and the greatest cause of tooth loss in adults. Diabetes has a significant impact on the gut microbiota; however, studies in the oral cavity have been inconclusive. By 16S rRNA sequencing, we show here that diabetes causes a shift in oral bacterial composition and, by transfer to germ-free mice, that the oral microbiota of diabetic mice is more pathogenic. Furthermore, treatment with IL-17 antibody decreases the pathogenicity of the oral microbiota in diabetic mice; when transferred to recipient germ-free mice, oral microbiota from IL-17-treated donors induced reduced neutrophil recruitment, reduced IL-6 and RANKL, and less bone resorption. Thus, diabetes-enhanced IL-17 alters the oral microbiota and renders it more pathogenic. Our findings provide a mechanistic basis to better understand how diabetes can increase the risk and severity of tooth loss. |
